HLA-DR and -DQ allelic sequences in multiple sclerosis patients are identical to those found in the general population.

doi:10.1016/0198-8859(91)90057-g

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Article

HLA-DR and -DQ allelic sequences in multiple sclerosis patients are identical to those found in the general population.

Human immunology - 1 Nov 1991

Cowan E P, Pierce M L, McFarland H F, McFarlin D E

Abstract excerpt

The HLA-DR2/Dw2 haplotype is associated with multiple sclerosis (MS) in the North American Caucasian population. HLA-DRB, -DQA, and -DQB N-terminal domain sequences derived from amplified cDNA in a series of North American Caucasian MS patients were examined to determine if unique or rare class I...

Topics

Alleles
Base Sequence
DNA
Female
HLA-DQ Antigens
HLA-DR Antigens
Humans
Male
Molecular Sequence Data
Multiple Sclerosis
Oligonucleotide Probes
Pedigree
Polymerase Chain Reaction
RNA
Sequence Homology, Nucleic Acid

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