A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway.

doi:10.1080/17446651.2025.2478068

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Article

A case-control study on SH2B1 gene variants in obesity and obstructive sleep apnea severity: genetic risk factors in the leptin signaling pathway.

Expert review of endocrinology & metabolism - 1 May 2025

Kuccukturk Serkan, Yosunkaya Sebnem, Karaselek Mehmet Ali, Demirel Sennur, Vural Hasibe

Abstract excerpt

BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep disorder, frequently observed in obese individuals, with shared mechanisms involving leptin and its receptor, which regulate appetite and energy expenditure. SH2B1 is a key enhancer of signaling in the leptin receptor pathway. This study aimed to investigate the association between SH2B1 variants and OSA. RESEARCH DESIGN AND METHODS: This case-control...

Read the complete abstract on PubMed

Topics

Humans
Sleep Apnea, Obstructive
Male
Case-Control Studies
Leptin
Obesity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Adult

Risk Factors

Polymorphism, Single Nucleotide

Adaptor Proteins, Signal Transducing

Signal Transduction

Genetic Predisposition to Disease

Body Mass Index

Genotype

Severity of Illness Index

Polysomnography

Source

Open in PubMed

Identifiers

PMID: 40103410
DOI: 10.1080/17446651.2025.2478068

Genes

SH2B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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