Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.

Obesity (Silver Spring, Md.) - 1 Feb 2008

Ge Dongliang, Gooljar Sakina B, Kyriakou Theodosios, Collins Laura J, Swaminathan Ramasamyiyer, Snieder Harold, Spector Tim D, O'Dell Sandra D

Abstract excerpt

The leptin signal is transduced via the JAK2-STAT3 (Janus kinase 2-signal transducer and activator of transcription-3) pathway at the leptin receptor. JAK2 also phosphorylates insulin receptor substrate, integral to insulin and leptin action and is required for optimum adenosine triphosphate-bind...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Gene Frequency
Share to Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Lipid Metabolism

Share to Polymorphism, Single Nucleotide

Share to Twins, Dizygotic

Share to Twins, Monozygotic

Source

Open in PubMed Open full text

Identifiers

PMID: 18239666
DOI: 10.1038/oby.2007.79
PMCID: PMC2289869

Genes

JAK2
ABCA1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18239666-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.PMID 18239666Read ↗

Association of common variants in JAK2 gene with reduced risk of metabolic syndrome and related disorders.Semantic proximity Read ↗

Common STAT3 variants are not associated with obesity or insulin resistance in female twins.Semantic proximity Read ↗

The SH2B gene is associated with serum leptin and body fat in normal female twins.Semantic proximity Read ↗

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population.Semantic proximity Read ↗

Protein tyrosine phosphatase-1B gene PTPN1: selection of tagging single nucleotide polymorphisms and association with body fat, insulin sensitivity, and the metabolic syndrome in a normal female population.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins.Semantic proximity Read ↗

Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.Semantic proximity Read ↗

Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.Semantic proximity Read ↗

INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample.Semantic proximity Read ↗

The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.