Article
Genetic and structural variation in the SH2B1 gene in the Belgian population.
Molecular genetics and metabolism - 1 Aug 2015
Aerts Evi, Beckers Sigri, Zegers Doreen, Van Camp Jasmijn K, Van Hoorenbeeck Kim, Massa Guy, Verrijken An, Mertens Ilse L, Verhulst Stijn L, Rooman Raoul R, Van Gaal Luc F, Van Hul Wim
Abstract excerpt
OBJECTIVE: Animal studies, genome-wide association and genomic structural variation studies have identified the SH2B1 gene as a candidate gene for obesity. Therefore, we have designed an extensive mutation and copy number variation (CNV) analysis investigating the prevalence of genetic and structural variations in SH2B1 in the Belgian population. DESIGN AND METHODS: In the first part of this study, we performed a...
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