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Article

The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.

Obesity facts - 1 Jan 2018

Giuranna Johanna, Volckmar Anna-Lena, Heinen Anna, Peters Triinu, Schmidt Börge, Spieker Anne, Straub Helena, Grallert Harald, Müller Timo D, Antel Jochen, Haußmann Ute, Klafki Hans, Rui Liangyou, Hebebrand Johannes, Hinney Anke

Abstract excerpt

OBJECTIVE: We aimed to determine the effect of human SH2B1 variants on leptin and insulin signaling, major regulators of energy homeostasis, on the RNA level. METHODS: We analyzed the expression of infrequent alleles of seven SH2B1 variants (Arg67Cys, Lys150Arg, Thr175Ala, Thr343Met, Thr484Ala, Ser616Pro and Pro689Leu) in response to insulin or leptin cell stimulation. Two of these were identified in own mutation...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29631267
DOI: 10.1159/000486962
PMCID: PMC5981666

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