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Comparison of Phylogenetically DistinctHistoplasmaStrains Reveals Evolutionarily Divergent Virulence Strategies

2 Jul 2014

Abstract excerpt

Infection with the dimorphic fungus Histoplasma capsulatum results from the inhalation of contaminated soil. Disease outcome is variable and depends on the immune status of the host, number of organisms inhaled, and the H. capsulatum strain. H. capsulatum is divided into seven distinct clades based on phylogenetic analyses, and strains from two separate clades have been identified in North America (denoted as NAm...

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PMID: 24987093
DOI: 10.1128/mbio.01376-14

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