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Article

RNA interference in Histoplasma capsulatum demonstrates a role for α‐(1,3)‐glucan in virulence

21 May 2004

Abstract excerpt

Histoplasma capsulatum is a fungal pathogen that causes respiratory and systemic disease by proliferating within macrophages. While much is known about histoplasmosis, only a single virulence factor has been defined, in part because of the inefficiency of Histoplasma reverse genetics. As an alternative to allelic replacement, we have developed a telomeric plasmid-based system for silencing gene expression in...

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PMID: 15225311
DOI: 10.1111/j.1365-2958.2004.04131.x

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