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Article

A Drug-Sensitive Genetic Network Masks Fungi from the Immune System

24 Apr 2006

Abstract excerpt

Fungal pathogens can be recognized by the immune system via their beta-glucan, a potent proinflammatory molecule that is present at high levels but is predominantly buried beneath a mannoprotein coat and invisible to the host. To investigate the nature and significance of "masking" this molecule, we characterized the mechanism of masking and consequences of unmasking for immune recognition. We found that the...

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PMID: 16652171
DOI: 10.1371/journal.ppat.0020035

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