Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 2007

Chabes Andrei, Stillman Bruce

Abstract excerpt

In eukaryotic cells the concentration of dNTP is highest in S phase and lowest in G1 phase and is controlled by ribonucleotide reductase (RNR). RNR activity is eliminated in all eukaryotes in G1 phase by a variety of mechanisms: transcriptional regulation, small inhibitory proteins, and protein degradation. After activation of RNR upon commitment to S phase, dATP feedback inhibition ensures that the dNTP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cell Cycle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromatin

Share to DNA Damage

Share to DNA, Fungal

Share to Nucleotides

Share to Promoter Regions, Genetic

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 17227840
DOI: 10.1073/pnas.0610585104
PMCID: PMC1783093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae.PMID 17227840Read ↗

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase.Semantic proximity Read ↗

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype.Semantic proximity Read ↗

Hydroxyurea arrests DNA replication by a mechanism that preserves basal dNTP pools.Semantic proximity Read ↗

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Semantic proximity Read ↗

Regulation of DNA replication during the yeast cell cycle.Semantic proximity Read ↗

DNA damage and cell cycle regulation of ribonucleotide reductase.Semantic proximity Read ↗

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage.Semantic proximity Read ↗

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.Semantic proximity Read ↗

A deoxynucleoside triphosphate triphosphohydrolase promotes cell cycle progression in <i>Caulobacter crescentus</i>Semantic proximity Read ↗

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cellsSemantic proximity Read ↗

A mammalian-like DNA damage response of fission yeast to nucleoside analogs.Semantic proximity Read ↗

DNA replication stress-induced loss of reproductive capacity in<i>S. cerevisiae</i>and its inhibition by caloric restrictionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.