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Article

Increased susceptibility to retinoid-induced teratogenesis in TGF-beta2 knockout mice.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2000

Nugent Paul, Pisano Michele M, Weinrich Martin C, Greene Robert M

Abstract excerpt

Transforming growth factor-beta (TGF-beta) and retinoic acid (RA) have been implicated in normal and abnormal embryonic development. The aim of this study was to investigate the effect of TGF-beta2 gene deletion on susceptibility to RA-induced teratogenesis in a mouse model. TGF-beta2 heterozygous or wild-type mice were mated and the dams dosed with a teratogenic dose of RA, or with control vehicle. The incidence...

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Source

Identifiers

PMID: 12401501
DOI: 10.1016/s0890-6238(02)00053-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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