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Article

Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice.

Human molecular genetics - 1 Jan 2014

Iwata Junichi, Suzuki Akiko, Pelikan Richard C, Ho Thach-Vu, Sanchez-Lara Pedro A, Chai Yang

Abstract excerpt

Mutations in transforming growth factor beta (TGFβ) receptor type II (TGFBR2) cause Loeys-Dietz syndrome, characterized by craniofacial and cardiovascular abnormalities. Mice with a deletion of Tgfbr2 in cranial neural crest cells (Tgfbr2(fl/fl);Wnt1-Cre mice) develop cleft palate as the result of abnormal TGFβ signaling activation. However, little is known about metabolic processes downstream of TGFβ signaling...

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Source

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Identifiers

PMID: 23975680
DOI: 10.1093/hmg/ddt410
PMCID: PMC3857953

Genes

TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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