Article
Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism.
Journal of cellular physiology - 1 Mar 2010
Baroni Tiziano, Bellucci Catia, Lilli Cinzia, Pezzetti Furio, Carinci Francesco, Lumare Eleonora, Palmieri Annalisa, Stabellini Giordano, Bodo Maria
Abstract excerpt
Nonsyndromic cleft lip with or without cleft palate (CLP) is a frequent craniofacial malformation caused by both genetic and environmental factors. Maternal smoking during pregnancy is a known risk factor, due to the teratogenic role of nicotine. To assess and compare the impact of CLP and nicoti...
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