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Article

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma

1 Aug 2007

Abstract excerpt

Melanoma consists 4-5 % of all skin cancers, but it contributes to 71-80 % of skin cancers deaths. UV light affects cell and tissue homeostasis due to its damaging effects on DNA integrity and modification of expression of a plethora of genes. DNA repair systems protect cells from UV-induced lesions. Several animal models of melanoma have been developed (Xiphophorus, Opossum Monodelphis domestica, mouse models...

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PMID: 18846265
DOI: 10.1586/17469872.2.4.451

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