Article
Allele and genotype frequency of MDR1 C3435T in Tamilian population.
Drug metabolism and pharmacokinetics - 1 Dec 2006
Ramasamy Kesavan, Sisy Sam Soya, Chandrasekaran Adithan
Abstract excerpt
The allele and genotype frequencies of MDR1 C3435T polymorphism were determined in 185 unrelated healthy Tamilians. The genomic DNA was extracted from peripheral leucocytes using phenol chloroform method and genotyped by PCR-RFLP method. The frequencies of MDR1 C3435 and T3435 alleles in Tamilian population were 0.46 and 0.54 respectively. The distribution of T3435 in this population was found to be greater than...
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