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Article

Thiopurine S-methyltransferase phenotype-genotype correlation in hemodialyzed patients.

Pharmacological reports : PR - 1 Jan 2000

Chrzanowska Maria, Kurzawski Mateusz, Droździk Marek, Mazik Marta, Oko Andrzej, Czekalski Stanisław

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme, catalyzing S-methylation of thiopurine drugs. TPMT exhibits autosomal codominant polymorphism. Patients carrying a variant genotype have low TPMT activity, and produce elevated levels of 6-thioguanine nucleotides (6-TGN) in their red blood cells (RBC). 6-TGN accumulation may result in azathioprine (AZA)-induced bone marrow myelosuppression in the course...

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Source

Identifiers

PMID: 17220558

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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