Article
A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility.
Molecular reproduction and development - 1 Jul 2007
Xu Eugene Yujun, Chang Rhoda, Salmon Nicholas A, Reijo Pera Renee A
Abstract excerpt
Members of the Pumilio (also called PUF) gene family belong to a class of highly conserved developmental regulators that are present in both flies and humans. Much is known about the function of Pumilio genes in invertebrate development, in particular their role as stem cell factors required for maintenance and/or self-renewal of germline stem cells in Drosophila and Caenorhabditis elegans. It remains unknown...
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