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Article

Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase.

Molecular cancer therapeutics - 1 Jan 2007

Holder Sheldon, Zemskova Marina, Zhang Chao, Tabrizizad Maryam, Bremer Ryan, Neidigh Jonathan W, Lilly Michael B

Abstract excerpt

The pim-1 kinase is a true oncogene that has been implicated in the development of leukemias, lymphomas, and prostate cancer, and is the target of drug development programs. We have used experimental approaches to identify a selective, cell-permeable, small-molecule inhibitor of the pim-1 kinase to foster basic and translational studies of the enzyme. We used an ELISA-based kinase assay to screen a diversity...

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Source

Identifiers

PMID: 17218638
DOI: 10.1158/1535-7163.MCT-06-0397

Genes

PIM1
PIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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