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Article

Characterizing a histidine switch controlling pH-dependent conformational changes of the influenza virus hemagglutinin.

Biophysical journal - 20 Aug 2013

Kalani Mohamad R, Moradi Abdulvahab, Moradi Mahmoud, Tajkhorshid Emad

Abstract excerpt

During the fusion of the influenza virus to the host cell, bending of the HA2 chain of hemagglutinin into a hairpin-shaped structure in a pH-dependent manner facilitates the fusion of the viral envelope and the endosomal membrane. To characterize the structural and dynamical responses of the hinge region of HA2 to pH changes and examine the role of a conserved histidine in this region (the hinge histidine), we...

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Identifiers

PMID: 23972851
DOI: 10.1016/j.bpj.2013.06.047
PMCID: PMC3752100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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