Article
The structure of a membrane fusion mutant of the influenza virus haemagglutinin.
The EMBO journal - 1 Jan 1990
Weis W I, Cusack S C, Brown J H, Daniels R S, Skehel J J, Wiley D C
Abstract excerpt
The haemagglutinin glycoprotein (HA) of influenza virus specifically mediates fusion of the viral and host cell endosomal membranes at the acidic pH of endosomes. The HAs from mutant viruses with raised fusion pH optima contain amino acid substitutions in regions of the HA structure thought to be...
Topics
- Crystallization
- Crystallography
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Hydrogen Bonding
- Hydrogen-Ion Concentration
- Molecular Structure
- Mutation
- Protein Conformation
- Viral Envelope Proteins