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Article

The influenza virus neuraminidase protein transmembrane and head domains have coevolved.

Journal of virology - 15 Jan 2015

da Silva Diogo V, Nordholm Johan, Dou Dan, Wang Hao, Rossman Jeremy S, Daniels Robert

Abstract excerpt

UNLABELLED: Transmembrane domains (TMDs) from single-spanning membrane proteins are commonly viewed as membrane anchors for functional domains. Influenza virus neuraminidase (NA) exemplifies this concept, as it retains enzymatic function upon proteolytic release from the membrane. However, the subtype 1 NA TMDs have become increasingly more polar in human strains since 1918, which suggests that selection pressure...

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Identifiers

PMID: 25378494
DOI: 10.1128/JVI.02005-14
PMCID: PMC4300628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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