Article
A G protein/cAMP signal cascade is required for axonal convergence into olfactory glomeruli.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007
Chesler Alexander T, Zou Dong-Jing, Le Pichon Claire E, Peterlin Zita A, Matthews Glennis A, Pei Xin, Miller Michael C, Firestein Stuart
Abstract excerpt
The mammalian odorant receptors (ORs) comprise a large family of G protein-coupled receptors that are critical determinants of both the odorant response profile and the axonal identity of the olfactory sensory neurons in which they are expressed. Although the pathway by which ORs activate odor transduction is well established, the mechanism by which they direct axons into proper glomerular relationships remains...
Topics
- Animals
- Axons
- Cell Differentiation
- Cyclic AMP
- GTP-Binding Proteins
- Mice
- Neurons, Afferent
- Olfactory Bulb
- Phenotype
- Receptors, G-Protein-Coupled
- Second Messenger Systems