Article
Odorant receptor-derived cAMP signals direct axonal targeting.
Science (New York, N.Y.) - 27 Oct 2006
Imai Takeshi, Suzuki Misao, Sakano Hitoshi
Abstract excerpt
In mammals, odorant receptors (ORs) direct the axons of olfactory sensory neurons (OSNs) toward targets in the olfactory bulb. We show that cyclic adenosine monophosphate (cAMP) signals that regulate the expression of axon guidance molecules are essential for the OR-instructed axonal projection. Genetic manipulations of ORs, stimulatory G protein, cAMP-dependent protein kinase, and cAMP response element-binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.