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Article

Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2007

Yang Yong, Sun Yinyan, Luo Xin, Zhang Yuxia, Chen Yaoyao, Tian E, Lints Robyn, Zhang Hong

Abstract excerpt

The molecular mechanisms underlying the formation of neurons with defined neurotransmitters are not well understood. In this study, we demonstrate that the PcG-like genes in Caenorhabditis elegans, sop-2 and sor-3, regulate the formation of dopaminergic and serotonergic neurons and several other neuronal properties. sor-3 encodes a novel protein containing an MBT repeat, a domain that contains histone-binding...

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Identifiers

PMID: 17215367
DOI: 10.1073/pnas.0610261104
PMCID: PMC1783403

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