Article
C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.
Journal of hypertension - 1 Feb 2007
Wessel Jennifer, Moratorio Guillermo, Rao Fangwen, Mahata Manjula, Zhang Lian, Greene William, Rana Brinda K, Kennedy Brian P, Khandrika Srikrishna, Huang Pauline, Lillie Elizabeth O, Shih Pei-An Betty, Smith Douglas W, Wen Gen, Hamilton Bruce A, Ziegler Michael G, Witztum Joseph L, Schork Nicholas J, Schmid-Schönbein Geert W, O'Connor Daniel T
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion. METHODS: CRP, as well as multiple facets of the metabolic syndrome, were measured in a series of 229 twins, both monozygotic (MZ) and dizygotic (DZ), to estimate trait heritability (h2)....
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