Article
Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.
PLoS medicine - 12 Aug 2008
Brunner Eric J, Kivimäki Mika, Witte Daniel R, Lawlor Debbie A, Davey Smith George, Cooper Jackie A, Miller Michelle, Lowe Gordon D O, Rumley Ann, Casas Juan P, Shah Tina, Humphries Steve E, Hingorani Aroon D, Marmot Michael G, Timpson Nicholas J, Kumari Meena
Abstract excerpt
BACKGROUND: Raised C-reactive protein (CRP) is a risk factor for type 2 diabetes. According to the Mendelian randomization method, the association is likely to be causal if genetic variants that affect CRP level are associated with markers of diabetes development and diabetes. Our objective was to examine the nature of the association between CRP phenotype and diabetes development using CRP haplotypes as...
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