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Article

Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.

Cell - 15 Jun 2007

Walkley Carl R, Shea Jeremy M, Sims Natalie A, Purton Louise E, Orkin Stuart H

Abstract excerpt

Hematopoiesis is maintained by stem cells (HSCs) that undergo fate decisions by integrating intrinsic and extrinsic signals, with the latter derived from the bone marrow (BM) microenvironment. Cell-cycle regulation can modulate stem cell fate, but it is unknown whether this represents an intrinsic or extrinsic effector of fate decisions. We have investigated the role of the retinoblastoma protein (RB), a central...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17574022
DOI: 10.1016/j.cell.2007.03.055
PMCID: PMC2768301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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