Article
FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage.
Developmental biology - 1 Mar 2011
Asanoma Kazuo, Rumi M A Karim, Kent Lindsey N, Chakraborty Damayanti, Renaud Stephen J, Wake Norio, Lee Dong-Soo, Kubota Kaiyu, Soares Michael J
Abstract excerpt
Differentiated trophoblast cell lineages arise from trophoblast stem (TS) cells. To date such a stem cell population has only been established in the mouse. The objective of this investigation was to establish TS cell populations from rat blastocysts. Blastocysts were cultured individually on a feeder layer of rat embryonic fibroblasts (REFs) in fibroblast growth factor-4 (FGF4) and heparin supplemented culture...
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