Article
Presence or absence of lipopolysaccharide O antigens affects type III secretion by Pseudomonas aeruginosa.
Journal of bacteriology - 1 Mar 2007
Augustin D K, Song Y, Baek M S, Sawa Y, Singh G, Taylor B, Rubio-Mills A, Flanagan J L, Wiener-Kronish J P, Lynch S V
Abstract excerpt
Pseudomonas aeruginosa is one of the major causative agents of mortality and morbidity in hospitalized patients due to a multiplicity of virulence factors associated with both chronic and acute infections. Acute P. aeruginosa infection is primarily mediated by planktonic bacteria expressing the type III secretion system (TTSS), a surface-attached needle-like complex that injects cytotoxins directly into...
Topics
- Animals
- Bacterial Proteins
- Bronchi
- Cell Line
- Cytotoxins
- Epithelial Cells
- Gene Expression Regulation, Bacterial
- Humans
- Lung
- Mice
- Mice, Inbred BALB C