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Article

A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection

20 Jul 2021

Abstract excerpt

Despite numerous efforts to develop an effective vaccine against Pseudomonas aeruginosa, no vaccine has yet been approved for human use. This study investigates the utility of the P. aeruginosa inherently produced polyhydroxyalkanaote (PHA) inclusions and associated host–cell proteins (HCP) as a particulate vaccine platform. We further engineered PHA inclusions to display epitopes derived from the outer membrane...

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PMID: 34358220
DOI: 10.3390/vaccines9070803

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