Article
wbp-encoded LPS O-antigen architecture as a prognostic and therapeutic target in Pseudomonas aeruginosa keratitis.
EBioMedicine - 1 Sept 2026
Wei Mingda, Zhang Zijun, Zhao Xudong, Xu Boling, Shi Qingquan, Cheng Zhen, Xu Xizhan, Wei Zhenyu, Lu Xinxin, Li Li, Liang Qingfeng
Abstract excerpt
BACKGROUND: Pseudomonas aeruginosa (P. aeruginosa) keratitis can progress rapidly to vision-threatening disease, even with intensive therapy. Virulence-associated genes are key determinants of ocular-surface pathogenesis. We therefore sought to develop a composite wbp-exo genotyping framework for risk stratification and to guide wbp-dependent, LPS-directed, levofloxacin-polymyxin B (LVX-POL) combination therapy...
Read the complete abstract on PubMedTopics
- Pseudomonas aeruginosa
- Keratitis
- Animals
- Humans
- Pseudomonas Infections
- O Antigens