Article
Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV).
Briefings in functional genomics & proteomics - 1 Nov 2005
Beutler Bruce, Georgel Philippe, Rutschmann Sophie, Jiang Zhengfan, Croker Ben, Crozat Karine
Abstract excerpt
Innate immunity is inherited and is, therefore, particularly susceptible to analysis by classical genetic methods. The 'phenotype first' approach has already revealed the principal receptors of the innate immune system as well as several essential signalling intermediates. It has recently emerged that innate resistance to mouse cytomegalovirus (MCMV) infection depends upon a large number of host genes with...
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