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Article

Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes

16 Apr 2020

Abstract excerpt

Multidrug resistance-1 (MDR1) acts as a chemotherapeutic drug efflux pump in tumor cells, although its physiological functions remain enigmatic. Using a recently developed MDR1-knockin reporter allele (Abcb1aAME), we found that constitutive MDR1 expression among hematopoietic cells was observed in cytolytic lymphocytes-including CD8+ cytotoxic T lymphocytes (CTLs) and natural killer cells-and regulated by...

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PMID: 32302378
DOI: 10.1084/jem.20191388

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