Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The interaction between streptomycin and ribosomal RNA.

Biochimie - 1 Dec 1991

Leclerc D, Melançon P, Brakier-Gingras L

Abstract excerpt

The present study shows that a mutation in the 530 loop of 16S rRNA impairs the binding of streptomycin to the bacterial ribosome, thereby restricting the misreading effect of the drug. Previous reports demonstrated that proteins S4, S5 and S12 as well as the 915 region of 16S rRNA are involved in the binding of streptomycin, and indicated that the drug not only interacts with the 30S subunit but also with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Binding Sites
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Mutation

Share to Nucleic Acid Conformation

Share to Plasmids

Share to Protein Biosynthesis

Source

Identifiers

PMID: 1725256
DOI: 10.1016/0300-9084(91)90175-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The interaction between streptomycin and ribosomal RNA.PMID 1725256Read ↗

Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.Semantic proximity Read ↗

A functional pseudoknot in 16S ribosomal RNA.Semantic proximity Read ↗

Streptomycin resistance in mycobacteria.Semantic proximity Read ↗

Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus.Semantic proximity Read ↗

The binding of thiostrepton to 23S ribosomal RNA.Semantic proximity Read ↗

Modulation of 16S rRNA function by ribosomal protein S12.Semantic proximity Read ↗

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.Semantic proximity Read ↗

Pleiotropic effects of mutations at positions 13 and 914 in Escherichia coli 16S ribosomal RNA.Semantic proximity Read ↗

Diverse effects of residues 74-78 in ribosomal protein S12 on decoding and antibiotic sensitivity.Semantic proximity Read ↗

23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.Semantic proximity Read ↗

Study of the function of Escherichia coli ribosomal RNA through site-directed mutagenesis.Semantic proximity Read ↗

Single-base mutations at position 2661 of Escherichia coli 23S rRNA increase efficiency of translational proofreading.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.