Article
The interaction between streptomycin and ribosomal RNA.
Biochimie - 1 Dec 1991
Leclerc D, Melançon P, Brakier-Gingras L
Abstract excerpt
The present study shows that a mutation in the 530 loop of 16S rRNA impairs the binding of streptomycin to the bacterial ribosome, thereby restricting the misreading effect of the drug. Previous reports demonstrated that proteins S4, S5 and S12 as well as the 915 region of 16S rRNA are involved i...
Topics
- Autoradiography
- Bacterial Proteins
- Binding Sites
- Dihydrostreptomycin Sulfate
- Drug Resistance, Microbial
- Escherichia coli
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Protein Biosynthesis
- RNA, Bacterial
- RNA, Ribosomal, 16S
- Streptomycin