Article
Novel mutants of 23S RNA: characterization of functional properties.
Nucleic acids research - 25 Jun 1992
Saarma U, Remme J
Abstract excerpt
Single point mutations corresponding to the positions G2505 and G2583 have been constructed in the gene encoding E.coli 23S rRNA. These mutations were linked to the second mutation A1067 to T, known to confer resistance to thiostrepton (1). Mutant ribosomes were analyzed in vitro for their abilit...
Topics
- Base Sequence
- Chloramphenicol
- Drug Resistance, Microbial
- Escherichia coli
- Lincomycin
- Magnesium
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Poly U
- Protein Biosynthesis
- Puromycin
- RNA, Bacterial
- RNA, Ribosomal, 23S
- Ribosomes
- Thiostrepton