Article
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Molecular cell - 4 Feb 2005
Huang Danny T, Paydar Amir, Zhuang Min, Waddell M Brett, Holton James M, Schulman Brenda A
Abstract excerpt
E2 conjugating enzymes play a central role in ubiquitin and ubiquitin-like protein (ublp) transfer cascades: the E2 accepts the ublp from the E1 enzyme and then the E2 often interacts with an E3 enzyme to promote ublp transfer to the target. We report here the crystal structure of a complex between the C-terminal domain from NEDD8's heterodimeric E1 (APPBP1-UBA3) and the catalytic core domain of NEDD8's E2...
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