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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

1 Mar 2016

Abstract excerpt

BACKGROUND: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases. MAIN BODY OF THE ABSTRACT: First, the composition, structure...

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PMID: 27222660
DOI: 10.1186/s13008-016-0020-7

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