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Article

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer

15 Jun 2009

Abstract excerpt

E3 ubiquitin ligases regulate many dynamic cellular processes important for cancer cell survival. Together with ubiquitin-activating enzyme (E1) and ubiquitin-conjugating enzymes (E2s), E3s catalyze the ubiquitination of numerous protein substrates that are subsequently targeted to the 26S proteasome for degradation. The clinical success of the proteasome inhibitor bortezomib has encouraged the evaluation of...

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PMID: 19509147
DOI: 10.1158/1078-0432.ccr-09-0343

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