Article
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution.
Nature genetics - 1 Feb 2007
Helgason Agnar, Pálsson Snaebjörn, Thorleifsson Gudmar, Grant Struan F A, Emilsson Valur, Gunnarsdottir Steinunn, Adeyemo Adebowale, Chen Yuanxiu, Chen Guanjie, Reynisdottir Inga, Benediktsson Rafn, Hinney Anke, Hansen Torben, Andersen Gitte, Borch-Johnsen Knut, Jorgensen Torben, Schäfer Helmut, Faruque Mezbah, Doumatey Ayo, Zhou Jie, Wilensky Robert L, Reilly Muredach P, Rader Daniel J, Bagger Yu, Christiansen Claus, Sigurdsson Gunnar, Hebebrand Johannes, Pedersen Oluf, Thorsteinsdottir Unnur, Gulcher Jeffrey R, Kong Augustine, Rotimi Charles, Stefánsson Kári
Abstract excerpt
We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a population attributable risk (PAR) of 17%-28% in three populations of European ancestry. Here, we refine the definition of the TCF7L2 type 2diabetes risk variant, HapB(T2D), to the ancestral T allele of a SNP, rs7903146, through replication in West African and...
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