Article
An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.
PloS one - 27 Dec 2006
Zhang Chi, Carl Timothy F, Trudeau Evan D, Simmet Thomas, Klymkowsky Michael W
Abstract excerpt
BACKGROUND: In both Drosophila and the mouse, the zinc finger transcription factor Snail is required for mesoderm formation; its vertebrate paralog Slug (Snai2) appears to be required for neural crest formation in the chick and the clawed frog Xenopus laevis. Both Slug and Snail act to induce epithelial to mesenchymal transition (EMT) and to suppress apoptosis. METHODOLOGY & PRINCIPLE FINDINGS: Morpholino-based...
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