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Article

SLUG in cancer development.

Oncogene - 28 Apr 2005

Pérez-Mancera Pedro Antonio, González-Herrero Inés, Pérez-Caro María, Gutiérrez-Cianca Noelia, Flores Teresa, Gutiérrez-Adán Alfonso, Pintado Belén, Sánchez-Martín Manuel, Sánchez-García Isidro

Abstract excerpt

The SNAIL-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to contribute to piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. While aberrant induction of SLUG has been documented in cancer cells, relatively little is known about the consequences of SLUG...

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Identifiers

PMID: 15735690
DOI: 10.1038/sj.onc.1208505

Genes

BCR
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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SLUG in cancer development.PMID 15735690Read ↗

SLUG: Critical regulator of epithelial cell identity in breast development and cancerSemantic proximity Read ↗

The Slug gene is not essential for mesoderm or neural crest development in mice.Semantic proximity Read ↗

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.Semantic proximity Read ↗

An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm.Semantic proximity Read ↗

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesisSemantic proximity Read ↗

Slug (SNAI2) Down-Regulation by RNA Interference Facilitates Apoptosis and Inhibits Invasive Growth in Neuroblastoma Preclinical ModelsSemantic proximity Read ↗

Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2)Semantic proximity Read ↗

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersSemantic proximity Read ↗

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.Semantic proximity Read ↗

Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8.Semantic proximity Read ↗

Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.Semantic proximity Read ↗

Zinc-finger transcription factor slug contributes to the survival advantage of chronic myeloid leukemia cellsSemantic proximity Read ↗

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