Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

30 Aug 2018

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a multistep dedifferentiation program important in tissue repair. Here, we examined the role of the transcriptional regulator NF-κB in EMT of primary human small airway epithelial cells (hSAECs). Surprisingly, transforming growth factor β (TGFβ) activated NF-κB/RELA proto-oncogene, NF-κB subunit (RELA) translocation within 1 day of stimulation, yet induction of its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related molecular mechanisms research
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30166344
DOI: 10.1074/jbc.ra118.003662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cellsPMID 30166344Read ↗

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transitionSemantic proximity Read ↗

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional RegulationSemantic proximity Read ↗

Activin Upregulation by NF-κB Is Required to Maintain Mesenchymal Features of Cancer Stem–like Cells in Non–Small Cell Lung CancerSemantic proximity Read ↗

Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transitionSemantic proximity Read ↗

Comparing transcriptional dynamics of the epithelial-mesenchymal transitionSemantic proximity Read ↗

NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype.Semantic proximity Read ↗

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.Semantic proximity Read ↗

RUNX1: A Regulator of NF-κB Signaling in Pulmonary DiseasesSemantic proximity Read ↗

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progressionSemantic proximity Read ↗

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transitionSemantic proximity Read ↗

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progressionSemantic proximity Read ↗

NF-kappaB and epithelial to mesenchymal transition of cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.