Article
Generation of a Snail1 (Snai1) conditional null allele.
Genesis (New York, N.Y. : 2000) - 1 Jan 2006
Murray Stephen A, Carver Ethan A, Gridley Thomas
Abstract excerpt
Members of the Snail gene superfamily, which encode zinc finger transcriptional repressors, play critical roles in the establishment of the vertebrate body plan. The Snail1 (Snai1) gene promotes epithelial-mesenchymal transitions during development and disease progression, and Snai1 null mouse embryos exhibit defects in gastrulation. However, the early embryonic lethality of Snai1 null embryos precludes the study...
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