Significant variation in haplotype block structure but conservation in tagSNP patterns among global populations.

doi:10.1038/sj.ejhg.5201751

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Article

Significant variation in haplotype block structure but conservation in tagSNP patterns among global populations.

European journal of human genetics : EJHG - 1 Mar 2007

Gu Sheng, Pakstis Andrew J, Li Hui, Speed William C, Kidd Judith R, Kidd Kenneth K

Abstract excerpt

The initial belief that haplotype block boundaries and haplotypes were largely shared across populations was a foundation for constructing a haplotype map of the human genome using common SNP markers. The HapMap data document the generality of a block-like pattern of linkage disequilibrium (LD) with regions of low and high haplotype diversity but differences among the populations. Studies of many additional...

Topics

Genetic Variation
Genetics, Population
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Synteny

Source

Open in PubMed

Identifiers

PMID: 17202997
DOI: 10.1038/sj.ejhg.5201751

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