Article
Haplotype block structures show significant variation among populations.
Genetic epidemiology - 1 Dec 2004
Liu Nianjun, Sawyer Sarah L, Mukherjee Namita, Pakstis Andrew J, Kidd Judith R, Kidd Kenneth K, Brookes Anthony J, Zhao Hongyu
Abstract excerpt
Recent studies suggest that haplotypes tend to have block-like structures throughout the human genome. Several methods were proposed for haplotype block partitioning and for tagging single-nucleotide polymorphism (SNP) identification. In population genetics studies, several research groups compared block structures across human populations. However, the measures used to quantify population similarity are either...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Genetic Predisposition to Disease
- Genetic Variation
- Genetics, Population
- Genome, Human
- Haplotypes
- Humans
- Models, Genetic
- Models, Statistical