Article
Using haplotype blocks to map human complex trait loci.
Trends in genetics : TIG - 1 Mar 2003
Cardon Lon R, Abecasis Gonçalo R
Abstract excerpt
Understanding of linkage disequilibrium (LD) in human populations could facilitate the discovery of genes that influence complex human diseases. The "HapMap" project is now underway to characterize patterns of LD in the human genome. A pilot study showed "haplotype blocks" in 51 regions scattered throughout the genome. These intriguing results raise important questions about the nature of recombination, and...
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