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Article

Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockouts

1 Jun 1997

Abstract excerpt

Analysis of mice with naturally occurring mutation in the genes encoding the tyrosine kinase receptor protein, c-kit, and its ligand, stem cell factor (SCF), has implicated these proteins in testicular development and function because of the phenotype of these mice of reduced or absent fertility. Descriptive and functional studies have highlighted the involvement of these proteins in primordial germ cell...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function
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Identifiers

PMID: 9203987
DOI: 10.1677/joe.0.1530337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stem cell factor and c-kit in the mammalian testis: lessons originating from Mother Nature's gene knockoutsPMID 9203987Read ↗

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Expression of c‐KIT and Its Ligand, Stem Cell Factor, in Normal and Subfertile Human Testicular TissueSemantic proximity Read ↗

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Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCFSemantic proximity Read ↗

Sertoli cells are the source of stem cell factor for spermatogenesisSemantic proximity Read ↗

Role of c-kit in mammalian spermatogenesisSemantic proximity Read ↗

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical ImplicationsSemantic proximity Read ↗

The kit ligand, stem cell factor.Semantic proximity Read ↗

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway.Semantic proximity Read ↗

The Germline Stem Cell Niche Unit in Mammalian TestesSemantic proximity Read ↗

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