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Zygotically Activated Genes Are Suppressed in Mouse Nuclear Transferred Embryos

1 Dec 2006

Abstract excerpt

Mammalian oocytes have the ability to confer totipotency to terminally differentiated somatic cell nuclei. Viable cloned animals have been produced by somatic cell nuclear transfer (NT) into oocytes in many mammalian species including mouse. However, the success rates of the production were quite low in all species. Many studies have measured differences in gene expression between NT and fertilized embryos in...

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PMID: 17196094
DOI: 10.1089/clo.2006.8.295

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