Article
[Association of lung function decline with the microsatellite polymorphism in the heme oxygenase-1 gene promoter, in a general population sample. Results from the Longitudinal European Community Respiratory Health Survey (ECRHS-France)].
Bulletin de l'Academie nationale de medecine - 1 Jan 2000
Aubier Michel, Guenegou Armelle, Benessiano Joëlle, Leynaert Bénédicte, Boczkowski Jorge, Neukirch Françoise
Abstract excerpt
Heme oxygenase (HO1) acts against oxidants which are thought to play a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD). A (GT)n repeat polymorphism in the HO1 gene promoter can modulate the transcription of this gene in response to oxidative stress. We postulated that this polymorphism might be associated with the degree and decline of lung function in subjects exposed to oxidative...
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