Article
Effect of oral N-acetylcysteine on COPD patients with microsatellite polymorphism in the heme oxygenase-1 gene promoter.
Drug design, development and therapy - 1 Jan 2015
Zhang Jia-Qiang, Zhang Jian-Qing, Fang Li-Zhou, Liu Ling, Fu Wei-Ping, Dai Lu-Ming
Abstract excerpt
BACKGROUND: Heme oxygenase-1 (HO-1) plays a protective role as an antioxidant in the lung, and HO-1 gene promoter polymorphism has been shown to be associated with the severity and prognosis of COPD patients. N-acetylcysteine (NAC), an antioxidant/mucous modifier, has shown an uncertain benefit in COPD patients. We hypothesized that this polymorphism could be associated with the effectiveness of oral NAC....
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