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Article

Antioxidant gene polymorphisms and susceptibility to a rapid decline in lung function in smokers.

American journal of respiratory and critical care medicine - 1 Aug 2002

He Jian-Qing, Ruan Jian, Connett John E, Anthonisen Nicholas R, Paré Peter D, Sandford Andrew J

Abstract excerpt

Oxidative stress is believed to play an important role in the pathogenesis of smoking-induced chronic obstructive pulmonary disease. We hypothesized that polymorphisms of antioxidant genes glutathione S-transferase M1 (GSTM1), GSTT1, GSTP1, and heme oxygenase-1 (HMOX1) would be associated with susceptibility to accelerated decline of lung function in smokers. We genotyped 621 subjects (299 rapid decliners [change...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12153964
DOI: 10.1164/rccm.2111059

Genes

GSTP1
HMOX1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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